Thiouracil in Treatment of Thyrotoxicosis

Thiouracil in Thyrotoxicosis

Juvenile thyrotoxicosis treated with thiouracil.

Prepubertal thyrotoxicosis is a condition of some rarity and comparatively few childhood cases have so far been recorded in the literature where the drug thiouracil has been used in treatment. A review of six cases so treated was published by Williams and Janney (1947). The present case provides a suitable example both of the clinical picture and the response to treatment. Atkinson (1938) in a ...

Sternal marrow studies in thyrotoxicosis treated with thiouracil and review of literature regarding thiouracil effects on blood.

A review of the available literature to date shows 1914 casest of thyrotoxicosis in which thiouracil was employed. This does not include the use of thiourea or other related compounds nor the use of thiouracil in any condition but thyrotoxicosis. Forty-four cases (1.3 per cent) had resulting agranulocytosis, and of these, i per cent) died because of the agranulocytosis. Ninety-three patients pe...

Surgical treatment of thyrotoxicosis.

A retrospective study of thyrotoxic patients treated by subtotal thyroidectomy between 2 and 21 years ago in the north-east of Scotland showed that 20% of the patients could not be identified or traced at the time of the survey. The thyroid status of 40% of patients followed up was abnormal.It is now accepted that radioiodine treatment of thyrotoxicosis is followed by a significant incidence of...

Treatment of thyrotoxicosis.

In this review, the causes of thyrotoxicosis and the treatment of syndromes with increased trapping of iodine are discussed. The benefits and the potential side effects of 3 frequently used therapies--antithyroid medications, thyroidectomy, and (131)I treatment--are presented. The different approaches to application of (131)I treatment are described. Treatment with (131)I has been found to be c...